I was able to compile and run my application on this Mac with the specified setup. From one day to another I couldn’t execute the application (even in Debug mode). The error occurs without any actual signing besides the things that are happening in the default debug/release build.

What I’ve tried to solve this issue:

• Made clean builds, even re-cloned the repository
• Restarted the MacBook (as specified in the official MacOS docs according to this signing error)
• Reinstalled QtCreator
• Run system updates (e.g. for the console tools)

I ran out of ideas what to do next. Any input is appreciated. In the following there is the MacOS crash report:

Process:               Sample [6739]
Path:                  /Users/USER/*/Sample.app/Contents/MacOS/Sample
Identifier:            com.yourcompany.Sample
Version:               ???
Code Type:             ARM-64 (Native)
Parent Process:        qtcreator_processlauncher [6187]
User ID:               501

Date/Time:             2022-06-10 09:56:06.0533 +0200
OS Version:            macOS 12.4 (21F79)
Report Version:        12
Anonymous UUID:        3C17814C-6324-03D6-2715-B4F55ACF44E5

Sleep/Wake UUID:       74437E44-7126-4975-8C2B-014AB410B1BE

Time Awake Since Boot: 35000 seconds
Time Since Wake:       6363 seconds

System Integrity Protection: enabled

Crashed Thread:        0

Exception Type:        EXC_BAD_ACCESS (SIGKILL (Code Signature Invalid))
Exception Codes:       UNKNOWN_0x32 at 0x0000000100db0000
Exception Codes:       0x0000000000000032, 0x0000000100db0000
Exception Note:        EXC_CORPSE_NOTIFY

Termination Reason:    Namespace CODESIGNING, Code 2 

VM Region Info: 0x100db0000 is in 0x100db0000-0x100dd0000;  bytes after start: 0  bytes before end: 131071
      REGION TYPE                    START - END         [ VSIZE] PRT/MAX SHRMOD  REGION DETAIL
      mapped file                 100d74000-100db0000    [  240K] r--/rwx SM=COW  ...t_id=e753674d
--->  mapped file                 100db0000-100dd0000    [  128K] r-x/rwx SM=COW  ...t_id=e753674d
      VM_ALLOCATE (reserved)      100dd0000-100dec000    [  112K] rw-/rwx SM=NUL  ...(unallocated)

Thread 0 Crashed:
0   dyld                                   0x100fa8008 dyld3::MachOFile::isMachO(Diagnostics&, unsigned long long) const + 20
1   dyld                                   0x100f892cc dyld4::Loader::mapSegments(Diagnostics&, dyld4::RuntimeState&, char const*, unsigned long long, dyld4::Loader::CodeSignatureInFile const&, bool, dyld3::Array<dyld4::Loader::Region> const&, bool, bool, dyld4::Loader::FileValidationInfo const&) + 1096
2   dyld                                   0x100f892cc dyld4::Loader::mapSegments(Diagnostics&, dyld4::RuntimeState&, char const*, unsigned long long, dyld4::Loader::CodeSignatureInFile const&, bool, dyld3::Array<dyld4::Loader::Region> const&, bool, bool, dyld4::Loader::FileValidationInfo const&) + 1096
3   dyld                                   0x100f8eb88 invocation function for block in dyld4::JustInTimeLoader::makeJustInTimeLoaderDisk(Diagnostics&, dyld4::RuntimeState&, char const*, dyld4::Loader::LoadOptions const&, bool, unsigned int) + 68
4   dyld                                   0x100f8e528 dyld4::JustInTimeLoader::withRegions(dyld3::MachOAnalyzer const*, void (dyld3::Array<dyld4::Loader::Region> const&) block_pointer) + 292
5   dyld                                   0x100f8eadc invocation function for block in dyld4::JustInTimeLoader::makeJustInTimeLoaderDisk(Diagnostics&, dyld4::RuntimeState&, char const*, dyld4::Loader::LoadOptions const&, bool, unsigned int) + 480
6   dyld                                   0x100f93d58 dyld4::SyscallDelegate::withReadOnlyMappedFile(Diagnostics&, char const*, bool, void (void const*, unsigned long, bool, dyld4::FileID const&, char const*) block_pointer) const + 132
7   dyld                                   0x100f8e8c8 dyld4::JustInTimeLoader::makeJustInTimeLoaderDisk(Diagnostics&, dyld4::RuntimeState&, char const*, dyld4::Loader::LoadOptions const&, bool, unsigned int) + 204
8   dyld                                   0x100f886d0 invocation function for block in dyld4::Loader::getLoader(Diagnostics&, dyld4::RuntimeState&, char const*, dyld4::Loader::LoadOptions const&) + 1384
9   dyld                                   0x100f87bc0 dyld4::Loader::forEachResolvedAtPathVar(dyld4::RuntimeState&, char const*, dyld4::Loader::LoadOptions const&, dyld4::ProcessConfig::PathOverrides::Type, bool&, void (char const*, dyld4::ProcessConfig::PathOverrides::Type, bool&) block_pointer) + 780
10  dyld                                   0x100f877ec invocation function for block in dyld4::Loader::forEachPath(Diagnostics&, dyld4::RuntimeState&, char const*, dyld4::Loader::LoadOptions const&, void (char const*, dyld4::ProcessConfig::PathOverrides::Type, bool&) block_pointer) + 148
11  dyld                                   0x100f7db18 dyld4::ProcessConfig::PathOverrides::forEachImageSuffix(char const*, dyld4::ProcessConfig::PathOverrides::Type, bool&, void (char const*, dyld4::ProcessConfig::PathOverrides::Type, bool&) block_pointer) const + 176
12  dyld                                   0x100f7e34c invocation function for block in dyld4::ProcessConfig::PathOverrides::forEachPathVariant(char const*, dyld3::Platform, bool, bool&, void (char const*, dyld4::ProcessConfig::PathOverrides::Type, bool&) block_pointer) const + 160
13  dyld                                   0x100f7d0f0 dyld4::ProcessConfig::PathOverrides::forEachInColonList(char const*, char const*, void (char const*, bool&) block_pointer) + 204
14  dyld                                   0x100f7dd9c dyld4::ProcessConfig::PathOverrides::forEachPathVariant(char const*, dyld3::Platform, bool, bool&, void (char const*, dyld4::ProcessConfig::PathOverrides::Type, bool&) block_pointer) const + 344
15  dyld                                   0x100f87740 dyld4::Loader::forEachPath(Diagnostics&, dyld4::RuntimeState&, char const*, dyld4::Loader::LoadOptions const&, void (char const*, dyld4::ProcessConfig::PathOverrides::Type, bool&) block_pointer) + 172
16  dyld                                   0x100f87f60 dyld4::Loader::getLoader(Diagnostics&, dyld4::RuntimeState&, char const*, dyld4::Loader::LoadOptions const&) + 864
17  dyld                                   0x100f8cb60 invocation function for block in dyld4::JustInTimeLoader::loadDependents(Diagnostics&, dyld4::RuntimeState&, dyld4::Loader::LoadOptions const&) + 380
18  dyld                                   0x100fa9264 invocation function for block in dyld3::MachOFile::forEachDependentDylib(void (char const*, bool, bool, bool, unsigned int, unsigned int, bool&) block_pointer) const + 148
19  dyld                                   0x100f75f98 dyld3::MachOFile::forEachLoadCommand(Diagnostics&, void (load_command const*, bool&) block_pointer) const + 168
20  dyld                                   0x100fa90ac dyld3::MachOFile::forEachDependentDylib(void (char const*, bool, bool, bool, unsigned int, unsigned int, bool&) block_pointer) const + 172
21  dyld                                   0x100f8c8c8 dyld4::JustInTimeLoader::loadDependents(Diagnostics&, dyld4::RuntimeState&, dyld4::Loader::LoadOptions const&) + 164
22  dyld                                   0x100f795c0 dyld4::prepare(dyld4::APIs&, dyld3::MachOAnalyzer const*) + 1092
23  dyld                                   0x100f7906c start + 488


Thread 0 crashed with ARM Thread State (64-bit):
    x0: 0x0000000100db0000   x1: 0x000000016f6edcd8   x2: 0x0000000000020000   x3: 0x0000000000040012
    x4: 0x0000000000000003   x5: 0x0000000000000000   x6: 0x0000000000000000   x7: 0x0000000000000000
    x8: 0x0000000100fec62c   x9: 0x0000000100fedea8  x10: 0x000000001e000000  x11: 0x0800000000028000
   x12: 0x0000000000000001  x13: 0x0000000000000001  x14: 0x0000000000011b00  x15: 0x0000000000000000
   x16: 0x00000000000000c5  x17: 0x6ae100016f6ed4b8  x18: 0x0000000000000000  x19: 0x000000016f6edcd8
   x20: 0x0000000100c70060  x21: 0x000000000003c000  x22: 0x0000000000000003  x23: 0x000000016f6ed7c8
   x24: 0x0000000000000040  x25: 0x0000000000000000  x26: 0x000000016f6ed54c  x27: 0x0000000000000000
   x28: 0x0000000100db0000   fp: 0x000000016f6ed110   lr: 0x7a6f800100f892cc
    sp: 0x000000016f6ed100   pc: 0x0000000100fa8008 cpsr: 0x00001000
   far: 0x0000000100db0000  esr: 0x92000007 (Data Abort) byte read Translation fault

Binary Images:
       0x100f74000 -        0x100fd3fff dyld (*) <d9c2a46e-8dc4-3950-9d6a-f799e8ccb683> /usr/lib/dyld
               0x0 - 0xffffffffffffffff ??? (*) <00000000-0000-0000-0000-000000000000> ???

External Modification Summary:
  Calls made by other processes targeting this process:
    task_for_pid: 0
    thread_create: 0
    thread_set_state: 0
  Calls made by this process:
    task_for_pid: 0
    thread_create: 0
    thread_set_state: 0
  Calls made by all processes on this machine:
    task_for_pid: 0
    thread_create: 0
    thread_set_state: 0

VM Region Summary:
ReadOnly portion of Libraries: Total=6048K resident=0K(0%) swapped_out_or_unallocated=6048K(100%)
Writable regions: Total=9360K written=0K(0%) resident=0K(0%) swapped_out=0K(0%) unallocated=9360K(100%)