ginalx’s answer should be set as the default one imo: this method allows for many optimizations.

The problem

Say that we have a list of items and on every item we want to include a menu that needs to be toggled. We include a toggle on a button that listens for a click event on itself (click)="toggle()", but we also want to toggle the menu whenever the user clicks outside of it. If the list of items grows and we attach a @HostListener('document:click') on every menu, then every menu loaded within the item will start listening for the click on the entire document, even when the menu is toggled off. Besides the obvious performance issues, this is unnecessary.

You can, for example, subscribe whenever the popup gets toggled via a click and start listening for “outside clicks” only then.

isActive: boolean = false;

// to prevent memory leaks and improve efficiency, the menu
// gets loaded only when the toggle gets clicked
private _toggleMenuSubject$: BehaviorSubject<boolean>;
private _toggleMenu$: Observable<boolean>;

private _toggleMenuSub: Subscription;
private _clickSub: Subscription = null;


constructor(
 ...
 private _utilitiesService: UtilitiesService,
 private _elementRef: ElementRef,
){
 ...
 this._toggleMenuSubject$ = new BehaviorSubject(false);
 this._toggleMenu$ = this._toggleMenuSubject$.asObservable();

}

ngOnInit() {
 this._toggleMenuSub = this._toggleMenu$.pipe(
      tap(isActive => {
        logger.debug('Label Menu is active', isActive)
        this.isActive = isActive;

        // subscribe to the click event only if the menu is Active
        // otherwise unsubscribe and save memory
        if(isActive === true){
          this._clickSub = this._utilitiesService.documentClickedTarget
           .subscribe(target => this._documentClickListener(target));
        }else if(isActive === false && this._clickSub !== null){
          this._clickSub.unsubscribe();
        }

      }),
      // other observable logic
      ...
      ).subscribe();
}

toggle() {
    this._toggleMenuSubject$.next(!this.isActive);
}

private _documentClickListener(targetElement: HTMLElement): void {
    const clickedInside = this._elementRef.nativeElement.contains(targetElement);
    if (!clickedInside) {
      this._toggleMenuSubject$.next(false);
    }    
 }

ngOnDestroy(){
 this._toggleMenuSub.unsubscribe();
}

And, in *.component.html:

<button (click)="toggle()">Toggle the menu</button>